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In 2022, the PubMed Central Database reported a total of 1443 publications on the subject of M1/M2 macrophages across various human conditions, along with 791 publications specifically focused on M1/M2 macrophages in specific organs (Figure 4.) Given their major involvement in the control of inflammation, cancer growth, atherosclerosis, infection, allergy, and transplant rejection, macrophages are polarized into diverse phenotypes according to the changes in their environment

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